Lupin seed γ-conglutin: Extraction and purification methods — A review

Abstract

Lupin is Australia’s largest legume crop, and its seeds contain γ-conglutin, a unique storage protein with demonstrated nutraceutical potential for controlling blood glucose levels and reducing the risk of type II diabetes. Despite growing interest in this protein’s bioactive properties, a comprehensive review of extraction and purification approaches had been lacking. This review examines reported extraction and purification methods for γ-conglutin from lupin seeds, analysing their advantages and limitations in the context of producing nutraceutical-grade material.

While various research groups have attempted to extract and purify proteins from lupin seeds, most focused on producing protein isolates as food ingredients rather than isolating γ-conglutin specifically. Existing methods were found to be time-consuming and unsuitable for commercial-scale production due to the multiple processing steps involved. This review provides a comprehensive analysis of reported γ-conglutin extraction and purification processes, establishing a foundation for developing novel, scalable purification techniques capable of delivering nutraceutical-grade γ-conglutin for clinical and commercial applications.

@article{mane2018tfst,
  title         = {Lupin seed \ensuremath{\gamma}-conglutin: Extraction
                  and purification methods-A review},
  shorttitle    = {Lupin seed \ensuremath{\gamma}-conglutin},
  author        = {Mane, Sharmilee P. and Johnson, Stuart K. and Duranti, Marcello and Pareek,
                  Vishnu K. and Utikar, Ranjeet P.},
  year          = 2018,
  journal       = {Trends in Food Science \& Technology},
  publisher     = {Elsevier},
  volume        = 73,
  pages         = {1--11},
  doi           = {10.1016/j.tifs.2017.12.008},
  url           = {https://www.sciencedirect.com/science/article/pii/S0924224417302509},
  urldate       = {2024-05-28}
}